TIMP-1 enhancer sequence – real or bacterial?
نویسندگان
چکیده
منابع مشابه
TIMP-1 in asthma
O ver the last few years there has been increasing interest in the matrix metalloproteinases (MMPs) in asthma. The MMPs are a family of over 20 zinc dependent endopeptidases with a range of substrate specificities. Although originally classified into gelatinases, stromolysins, collagenases, and matrilysins by their ability to cleave extracellular matrix components, it is now clear that MMPs hav...
متن کاملFunctional roles of the pre-sensor I insertion sequence in an AAA+ bacterial enhancer binding protein
Molecular machines belonging to the AAA+ superfamily of ATPases use NTP hydrolysis to remodel their versatile substrates. The presence of an insertion sequence defines the major phylogenetic pre-sensor I insertion (pre-SIi) AAA+ superclade. In the bacterial sigma(54)-dependent enhancer binding protein phage shock protein F (PspF) the pre-SIi loop adopts different conformations depending on the ...
متن کاملThe bacterial enhancer-dependent RNA polymerase
Transcription initiation is highly regulated in bacterial cells, allowing adaptive gene regulation in response to environment cues. One class of promoter specificity factor called sigma54 enables such adaptive gene expression through its ability to lock the RNA polymerase down into a state unable to melt out promoter DNA for transcription initiation. Promoter DNA opening then occurs through the...
متن کاملSeismic Data Forecasting: A Sequence Prediction or a Sequence Recognition Task
In this paper, we have tried to predict earthquake events in a cluster of seismic data on pacific ring of fire, using multivariate adaptive regression splines (MARS). The model is employed as either a predictor for a sequence prediction task, or a binary classifier for a sequence recognition problem, which could alternatively help to predict an event. Here, we explain that sequence prediction/r...
متن کاملTIMP-1 alters susceptibility to carcinogenesis.
Tissue inhibitors of metalloproteinases (TIMPs) are a family of multifunctional proteins known to possess a broad range of biological activities, including inhibition of metalloproteinase activity, regulation of proliferation and apoptosis of a variety of cell types, and, depending on the context, differential regulation of angiogenic and inflammatory responses. Elevated mRNA expression of TIMP...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2003
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6601353